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Publications Summary
These are the publications from GC6 studies.
2010
Repsilber D, Kern S, Telaar A, Walzl G, Black GF, Selbig J, Parida SK, Kaufmann SH, Jacobsen M. Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach. BMC Bioinformatics. 2010 Jan 14;11:27.
2009
Lalor MK, Smith SG, Floyd S, Gorak-Stolinska P, Weir RE, Blitz R, Branson K, Fine PE, Dockrell HM. Complex cytokine profiles induced by BCG vaccination in UK infants. Vaccine. 2010 Feb 10;28(6):1635-1641. Epub 2009 Nov 24.
Lin MY, Reddy TB, Arend SM, Friggen AH, Franken KL, van Meijgaarden KE, Verduyn MJ, Schoolnik GK, Klein MR, Ottenhoff TH. Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria. Infect Immun. 2009 Nov;77(11):5071-9. Epub 2009 Sep 8.
Ottenhoff TH. Overcoming the global crisis: "yes, we can", but also for TB ... ? Eur J Immunol. 2009 Aug;39(8):2014-20.
Parida SK, Kaufmann SH. The quest for biomarkers in tuberculosis. Drug Discov Today. 2009 Oct 23.
Sutherland JS, Jeffries DJ, Donkor S, Walther B, Hill PC, Adetifa IM, Adegbola RA, Ota MO. High granulocyte/lymphocyte ratio and paucity of NKT cells defines TB disease in a TB-endemic setting. Tuberculosis (Edinb). 2009 Nov;89(6):398-404. Epub 2009 Aug 14.
Black GF, Thiel BA, Ota MO, Parida SK, Adegbola R, Boom WH, Dockrell HM, Franken KL, Friggen AH, Hill PC, Klein MR, Lalor MK, Mayanja H, Schoolnik G, Stanley K, Weldingh K, Kaufmann SH, Walzl G, Ottenhoff TH; GCGH Biomarkers for TB Consortium. Immunogenicity of novel DosR regulon-encoded candidate antigens 1 of Mycobacterium 2 tuberculosis in three high-burden populations in Africa. Clinical and Vaccine Immunology, August 2009, p.1203-1212, Vol.16, No.8.
Sutherland JS, Adetifa IMO, Hill PC, Adegbola RA, Ota MOC. Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur J Immunol 2009: 39:723-729.
Lalor MK, Ben-Smith A, Gorak-Stolinska P, Weir RE, Floyd S, Blitz, R, Mvula H, Newport MJ, Branson K, McGrath N, Crampin AC, Fine PE, Dockrell HM. Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy. J Infect Dis, 2009; 199(6):795-800
Djoba Siawaya JF, Chegou NN, van den Heuvel MM, Diacon AH, Beyers N, van Helden P, Walzl G. Differential cytokine/chemokines and KL-6 profiles in patients with different forms of tuberculosis. Cytokine. 2009 Aug;47(2):132-6. Epub 2009 Jun 30.
Detjen AK, Loebenberg L, Grewal HM, Stanley K, Gutschmidt A, Kruger C, Du Plessis N, Kidd M, Beyers N, Walzl G, Hesseling AC. Short-term reproducibility of a commercial interferon gamma release assay. Clin Vaccine Immunol. 2009 Aug;16(8):1170-5. Epub 2009 Jun 17.
Chegou NN, Black GF, Kidd M, van Helden PD, Walzl G. Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report. BMC Pulm Med. 2009 May 16;9:21.
Djoba Siawaya JF, Beyers N, van Helden P, Walzl G. Differential cytokine secretion and early treatment response in patients with pulmonary tuberculosis. Clin Exp Immunol. 2009 Apr;156(1):69-77. Epub 2009 Jan 22.
2008
Magdorf K, Schuck SD, Leitner S, Wahn U, Kaufmann SH, Jacobsen M. T-cell responses against tuberculin and sensitin in children with tuberculosis and non-tuberculosis mycobacterial lymphadenopathy. Clin Microbiol Infect 14: 1079-1083.
Ritz N, Hanekom WA, Robins-Browne R, Britton WJ, Curtis N. Influence of BCG vaccine stain on the immune response and protection against tuberculosis. FEMS Microbiol Rev 32: 821-841
Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G. An evaluation of commercial fluorescent bead-based luminex cytokine assays. PLoS ONE. 2008 Jul 2;3(7):e2535.
Garcia-Contreras L, Wong YL, Muttil P, Padilla D, Sadoff J, Derousse J, Germishuizen WA, Goonesekera S, Elbert K, Bloom BR, Miller R, Fourie PB, Hickey A, Edwards D. Immunization by a bacterial aerosol. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4656-60. Epub 2008 Mar 14.
Hanekom WA, Dockrell HM, Ottenhoff TH, Doherty TM, Fletcher H, McShane H, Weichold FF, Hoft DF, Parida SK, Fruth UJ. Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. PLoS Med. 2008 Jul 1;5(7):e145.
Hesseling AC, Mandalakas AM, Kirchner LH, Chegou NN, Marais BJ, Zhu X, Black GF, Stanley K, Beyers N, Walzl G. Highly Discordant T-Cell Responses In Individuals With Recent Household Tuberculosis Exposure. Thorax. 2008 Aug 5.
Jacobsen M, Mattow J, Repsilber D, Kaufmann SH. Novel strategies to identify biomarkers in tuberculosis. Biol Chem. 2008 Mar 6.
Kaufmann SH, Parida SK. Tuberculosis in Africa: learning from pathogenesis for biomarker identification. Cell Host Microbe. 2008 Sep 11;4(3):219-28.
Kaufmann SH. Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff. Nat Immunol. 2008 Jul;9(7):705-12.
Kaufmann SH. Paul Ehrlich: founder of chemotherapy. Nat Rev Drug Discov. 2008 May;7(5):373.
Lin MY, Ottenhoff TH. Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection. Biol Chem. 2008 Mar 6.
Lin MY, Ottenhoff TH. Host-pathogen interactions in latent Mycobacterium tuberculosis infection: identification of new targets for tuberculosis intervention. Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):15-29.
Mandalakas AM, Hesseling AC, Chegou NN, Kirchner HL, Zhu X, Marais BJ, Black GF, Beyers N, Walzl G. High level of discordant IGRA results in HIV-infected adults and children. Int J Tuberc Lung Dis. 2008 Apr;12(4):417-23.
Mueller H, Detjen AK, Schuck SD, Gutschmidt A, Wahn U, Magdorf K, Kaufmann SH, Jacobsen M. Mycobacterium tuberculosis-specific CD4+, IFNgamma+, and TNFalpha+ multifunctional memory T cells coexpress GM-CSF.Cytokine. 2008 Aug;43(2):143-8.
Soares AP, Scriba TJ, Joseph S, Harbacheuski R, Murray RA, Gelderbloem SJ, Hawkridge A, Hussey GD, Maecker H, Kaplan G, Hanekom WA. Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J Immunol. 2008 Mar 1;180(5):3569-77.
Scriba TJ, Kalsdorf B, Abrahams DA, Isaacs F, Hofmeister J, Black G, Hassan HY, Wilkinson RJ, Walzl G, Gelderbloem SJ, Mahomed H, Hussey GD, Hanekom WA. Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol. 2008 Feb 1;180(3):1962-70.
Walzl G, Ronacher K, Djoba Siawaya JF, Dockrell HM. Biomarkers for TB treatment response: challenges and future strategies. J Infect. 2008 Aug;57(2):103-9.
Zvi A, Ariel N, Fulkerson J, Sadoff JC, Shafferman A. Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses. BMC Med Genomics. 2008 May 28;1:18.
2007
Geluk A, Lin MY, van Meijgaarden KE, Leyten EM, Franken KL, Ottenhoff TH, Klein MR. T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination. Infect Immun. 2007 Jun;75(6):2914-21. Epub 2007 Mar 26. PMID: 17387166
Mandalakas AM, Hesseling AC, Chegou N, Kirchner HL, Zhu X, Marais BJ, Black GF, Beyers N and Walzl G. High level of discordant IGRA results in HIV-infected adults and children. Int J Tuberc Lung Dis 2008 Apr; 12(4):417-23. PMID: 18371268
Jacobsen M, Repsilber D, Gutschmidt A, Neher A, Feldmann K, Mollenkopf HJ, Ziegler A, Kaufmann SH. Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med. 2007 Jun;85(6):613-21. Epub 2007 Feb 23. PMID: 17318616.
Jacobsen M, Detjen AK, Mueller H, Gutschmidt A, Leitner S, Wahn U, Magdorf K, Kaufmann SH. Clonal expansion of CD8+ effector T cells in childhood tuberculosis. J Immunol. 2007 Jul 15;179(2):1331-9. PMID: 17617626.
Kaufmann SH and Parida SK. (2007) Changing funding patterns in Tuberculosis. Nat Med.13(3):299-303. Review
Lin MY, Geluk A, Smith SG, Stewart AL, Friggen AH, Franken KL, Verduyn MJ, van Meijgaarden KE, Voskuil MI, Dockrell HM, Huygen K, Ottenhoff TH, Klein MR. Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. Infect Immun. 2007 Jul;75(7):3523-30. Epub 2007 May 14. PMID: 17502400
Rachman H, Kaufmann SH. Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Int J Med Microbiol. 2007 Nov;297(7-8):559-67. Epub 2007 Apr 27. PMID: 17467338
Radosevic K, Wieland CW, Rodriguez A, Weverling GJ, Mintardjo R, Gillissen G, Vogels R, Skeiky YA, Hone DM, Sadoff JC, van der Poll T, Havenga M, Goudsmit J. Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon. Infect Immun. 2007 Aug;75(8):4105-15. Epub 2007 May 25. PMID: 17526747
Sadoff JC, Wittes J. Correlates, surrogates, and vaccines. J Infect Dis. 2007 Nov 1;196(9):1279-81. Epub 2007 Oct 2. PMID: 17922389
Weichold FF, Mueller S, Kortsik C, Hitzler WE, Wulf MJ, Hone DM, Sadoff JC, Maeurer MJ. Impact of MHC class I alleles on the M. tuberculosis antigen-specific CD8+ T-cell response in patients with pulmonary tuberculosis. Genes Immun. 2007 Jun;8(4):334-43. Epub 2007 Apr 12. PMID: 17429413
2006
Baumann S, Nasser Eddine A, Kaufmann SH. Progress in tuberculosis vaccine development. Curr Opin Immunol. 2006 Aug;18(4):438-48. Epub 2006 Jun 13. Review. PMID: 16777396
Jacobsen M, Repsilber D, Gutschmidt A, Neher A, Feldmann K, Mollenkopf HJ, Ziegler A, Kaufmann SH. Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. J Infect Dis. 2005 Oct 1;192(7):1211-8. Epub 2005 Aug 24. PMID: 16136464
Jacobsen M, Repsilber D, Gutschmidt A, Neher A, Feldmann K, Mollenkopf HJ, Kaufmann SH, Ziegler A. Deconfounding microarray analysis - independent measurements of cell type proportions used in a regression model to resolve tissue heterogeneity bias. Methods Inf Med. 2006;45(5):557-63. PMID: 17019511
Jacobsen M, Repsilber D, Gutschmidt A, Neher A, Feldmann K, Mollenkopf HJ, Ziegler A, Kaufmann SH. Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med. 2007 Jun;85(6):613-21. Epub 2007 Feb 23. PMID: 17318616
Jeffries DJ, Hill PC, Fox A, Lugos M, Jackson-Sillah DJ, Adegbola RA, Brookes RH. Identifying ELISPOT and skin test cut-offs for diagnosis of Mycobacterium tuberculosis infection in The Gambia. Int J Tuberc Lung Dis. 2006 Feb;10(2):192-8. PMID: 16499260
Kaufmann SH. Envisioning future strategies for vaccination against tuberculosis. Nat Rev Immunol. 2006 Sep;6(9):699-704. Epub 2006 Aug 18. PMID: 16917508
Kaufmann SH, Baumann S, Nasser Eddine A. Exploiting immunology and molecular genetics for rational vaccine design against tuberculosis. Int J Tuberc Lung Dis. 2006 Oct;10(10):1068-79. Review. PMID: 17044198
Leyten EM, Lin MY, Franken KL, Friggen AH, Prins C, van Meijgaarden KE, Voskuil MI, Weldingh K, Andersen P, Schoolnik GK, Arend SM, Ottenhoff TH, Klein MR. Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis. Microbes Infect. 2006 Jul;8(8):2052-60. Epub 2006 Jun 13. PMID: 16931093
Nasser Eddine, A., S. Baumann and S.H.E. Kaufmann. New Tuberculosis Vaccines Approaching Clinical Trial – An Overview. Drug Discovery Today: Therapeutic Strategies Volume 3, Issue 2, Summer 2006, Pages 113-119
Rachman H, Strong M, Schaible U, Schuchhardt J, Hagens K, Mollenkopf H, Eisenberg D, Kaufmann SH. Mycobacterium tuberculosis gene expression profiling within the context of protein networks. Microbes Infect. 2006 Mar;8(3):747-57. Epub 2006 Jan 18. PMID: 16513384
Rachman H, Strong M, Ulrichs T, Grode L, Schuchhardt J, Mollenkopf H, Kosmiadi GA, Eisenberg D, Kaufmann SH. Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis. Infect Immun. 2006 Feb;74(2):1233-42. PMID: 16428773
Rachman H, Lee JS, Angermann J, Kowall J, Kaufmann SH. Reliable amplification method for bacterial RNA. J Biotechnol. 2006 Oct 20;126(1):61-8. Epub 2006 Apr 17. PMID: 16603269
Skeiky YA, Sadoff JC. Advances in tuberculosis vaccine strategies. Nat Rev Microbiol. 2006 Jun;4(6):469-76. Review. PMID: 16710326